COTW: 3/14/22: 60 year old male with hoarseness

A 60 year old male with history of lung cancer presents to the ED with hoarseness. Patient is deaf and requires ASL. Patient also endorses sore throat and difficulty in breathing. Vital signs: BP 90/40, HR 120, RR 20, O2 94% RA, T 98.5. Physical exam: patient tachypneic, uncomfortable appearing and using accessory muscles to breath, patient is unable to lie supine. Airway patent without exudates or evidence of Ludwig’s, peritonsillar or retropharyngeal abscess. While waiting for ASL translation POCUS was used for evaluation.

Bedside ultrasound showed the following:

Large pericardial effusion in PLAX view.

Large pericardial effusion with evidence of RV free wall collapse. PSL view.

Pericardial Effusion/Tamponade

Common symptoms:

  • Exercise intolerance/dyspnea on exertion

  • Cough

  • Fatigue/shortness of breath

  • Pleuritic chest pain

  • Hiccups: phrenic nerve irritation/compression

  • Hoarseness!!!!

    • Recurrent laryngeal nerve compression

    • The left recurrent laryngeal nerve lies near the aorto-pulmonary window. Enlarged mediastinal lymph nodes (as well as inflammation pressing against the nodes) cause compression of such nerve and leads to hoarseness

    • Recurrent laryngeal nerve paralysis as a result of cardiovascular disease is also called “Ortner’s syndrome”

      • it results from the proximity of the heart and vessels

        • Pericardial effusion

        • Left atrial enlargement

        • Mitral stenosis

        • Penetratring aortic ulcer, patent ductus arteriosus (PAD), aortic aneurysm, giant cell arteritis

    • Left recurrent laryngeal 1.75X more common to be affected than the right

Physical Exam

  • Pulses paradoxus: 82% sensitive

  • Tachycardia: 77% sensitive

  • Tachypnea

  • Friction rub

  • Hypotension (narrow pulse pressure)

  • Muffled heart sounds

Causes:

  • Pericarditis

  • Uremia

  • Myopericarditis

  • Malignancy

    • Lung cancer, Hodgkin lymphoma, non-Hodgkin lymphoma, leukemia

  • Infections

  • Lupus

  • Hypothyroidism

  • Post-radiation: effusion may occur up to 20 years after therapy

  • Trauma

*** Reminder: It is not the size of the effusion, but the velocity that it accumulates that leads to cardiac tamponade. As little as 150-200mL of fluid can cause tamponade if the filling occurs quickly ***

*** The pericardial space is normally filled with <50 ml of fluid ***

Rapidly accumulating pericardial effusion can increase the pericardial pressures significantly and lead to tamponade.

Image Acquisition

Pericardial effusion is seen anterior to the descending aorta as portrayed in image. Pleural effusion is posterior to the descending aorta.

Work Up

  • CXR, CBC, Trop/BNP, coags, type and screen

  • EKG

    • Low voltage QRS

    • Electrical alternans

    • Non-specific ST/T wave changes

POCUS and Tamponade

  • Lower complication rate when compared to blind approach

    • 0.5%-3.7 with ultrasound vs 15-20% blind

  • Allows operator to visualize real-time needle throughout the entire procedure

  • ECHO findings of Tamponade:

    • Pericardial effusion

    • Right atrial collapse during systole: earliest sign. Collapse lasts > 1/3 of cardiac cycle.

    • Right ventricular collapse during diastole: high specificity (75-90%)

    • Plethoric and non-variable IVC: high sensitivity (95-97%)

    • Mitral valve inflow decrease of >25% <———DR. ABRAMS SPECIAL!!!!!

      • Tricuspid valve inflow increase of >40%

      • Surrogate for pulsus paradoxus

*** Patients that have elevated right side pressures, diastolic collapse will less likely occur ***

  • Size:

    • Small < 1cm. Volume 50-100 ml

    • Moderate 1-2 cm. Volume 100-500 ml

    • Large >2cm. Volume > 500ml

***Pericardial fat pad: moves with heart during the cardiac cycle. Distributed in anterior atrioventricular groove***

Fat pad visualized anteriorly is iso-echoic versus pericardial effusion (anechoic).


Pericardiocentesis

  • Potential complications

    • Right ventricular puncture

    • Pneumothorax

    • Gastric puncture

    • Liver puncture

    • Hemorrhage

    • Ventricular arrhythmia

    • Pulmonary edema (pericardial decompression syndrome)

      • May develop few hours to days later. Occurs due to acute left ventricular overload secondary to persistent catecholaminergic peripheral vasoconstriction.

  • Contraindications

    • Aortic dissection

    • Free wall rupture

  • What do you need?…

Approach

Subxiphoid

  • Highest complication rate

  • Potential structures to be damages: liver, lung, IVC, internal thoracic artery, left anterior descending aorta, colon and stomach

  • Longest distance from skin to pericardial fluid

Subxiphoid approach. Insert needle (not in plane) between xiphoid and left costal margin. Aim to left shoulder.

Parasternal

  • Shorter skin to pericardium distance

  • Complication: internal mammary artery (on lateral edge of sternum), pneumothorax

  • Limited in cardiac arrest

Parasternal approach. Insert needle in at/close to 5th left intercostal space. Needle in plane aiming to patient’s right shoulder.

Apical

  • Use high-frequency (linear) probe!!

  • Shortest skin to pericardium distance

  • Complication: pneumothorax, ventricular puncture


Apical approach: Introduce needle over the superior border of the adjacent rib to avoid intercostal nerves/vessels. Needle is introduced lateral to ribs 5-7. Aim towards the patient's right shoulder.

Pericardiocentesis: apical approach. Needle visualized top right of screen.

Apical approach using high-frequency probe. Needle visualized top right of screen.

Teaching Points

  • Rate of accumulation is predicting of tamponade rather than the size of effusion

  • Pericardiocentesis PLAX and apical approach have less complications when compared to SubX approach

  • Choose the site with the largest effusion closest to the probe

  • PLAX approach is favored but it is limited in cardiac arrest during cardiopulmonary resuscitation

  • Remember atypical presentations: hoarseness, hiccups

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COTW 3/7/22: 24 year old female with abdominal pain